Synedrex Review – 13 Things You Need to Know

Synedrex Review 

											- 13 Things You Need to Know
ora organic

With only one pill a day, Synedrex claims it can help you increase energy levels and the metabolic rate. The pill claims to be “the most powerful thermogenic agent on the market.” Upon further research into their ingredient list, including bitter orange and hordenine, it is clear that science may not back these claims.

Our research team looked into their “scientifically researched and proven ingredients,” product warnings, and the discounts available online and in-store to learn more about this diet pill. In the end, we compared the ingredient research on Jarensis extract and Yohimbe to the customer reviews on the Metabolic Nutrition official website to see if this is worth the money.

Synedrex can be purchased through their Official Site.

Synedrex Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

Synedrex Video Review


What is Synedrex?

Synedrex pills are marketed as a thermogenic supplement designed to burn fat and boost your metabolism to reduce weight and inches.

Synedrex pills are sold via the web both from the manufacturer’s website and several other online retail sites, and this is what the research has to say about the ingredients:

Synedrex Competitors


How Did Synedrex Start?

There is no information available as to when Synedrex was first marketed.

Synedrex original was manufactured with the, now banned, chemical DMAA. This formulation was withdrawn with the banning of DMAA, and Synedrex’s new formula was brought onto the market.

The manufacturer is Metabolic Nutrition Inc, based in Tamarac, Florida. The company manufactures and sells a range of nutritional supplements that include weight loss supplements, vitamins, and other health and muscle mass supplements. Their products include Protizyme, Tri-pep, Musclean, Hydravax, E.s.p. Extreme, Carni-10, Myogrow, and they also offer lifestyle gear.

Metabolic Nutrition Inc. Customer service contact information:
10151 NW 67th Street
Tamarac, FL 33321

1-800-626-1022 9:00 am – 5:00 pm EST, Monday through Friday.
Email: [email protected]
[email protected]


Synedrex Claims

The manufacturer claims that Synedrex weight loss pills have been scientifically engineered to ensure that all the ingredients work synergistically to ensure that the user maintains their energy levels and avoids the energy slump common with the use of products that contain powerful stimulants.

The manufacturer claims that Synedrex weight loss is possible. Still, the product will energize you, suppress your appetite, accelerate your weight loss, enhance your mental clarity and concentration, and improve your mood.

The manufacturer also claims to use ingredients that are scientifically researched and proven in this product.

Synedrex claims

When looking at the weight loss section, a similar set of blog-style articles was found but no scientific research.

The articles listed are not current, and this site is infrequently updated. The latest four articles are dated April 2016, October 2016, and December 2016.

Metabolic Nutrition also touts the Thyrene and Synedrex stack to boost your weight loss regime.

The claim is that the consumer “will lose weight with the Synedrex weight loss pills, but by taking Thyrene at the same time, you will improve your thyroid function, which will aid in boosting your metabolism.”

Thyrene is not a stimulant, so, according to the manufacturer.


Synedrex Ingredients

The Synedrex weight loss pill claims to be a successful weight and inch loss formulation. The Synedrex ingredients in this product are:

  • Caffeine Anhydrous
  • Eria Jarensis Extract
  • Grains of Paradise
  • Bitter Orange
  • Yohimbine HCL
  • Higenamine
  • Hordenine
  • Huperzine A
  • Naringin
  • N-Methylphenethylamine
  • L-Dopa
  • Poly-Thyronine

Additional Information on the Ingredients

Caffeine Anhydrous

Anhydrous caffeine is nothing more than dried caffeine available in a powder form that has many uses.

Caffeine is listed as a nervous system stimulant and is defined as being a substance that will be habit-forming rather than one that is addictive, according to the journal Brain Research Reviews

The problems arise when someone that regularly takes large intakes of caffeine stops; they may be subject to withdrawal symptoms such as nausea, headaches, and fatigue.

The International Society of Sports Nutrition claims that caffeine is beneficial for athletes engaged in extended exercise (endurance races) and high-intensity exercise (rugby or football) rather than strength exercises such as weightlifting.

Synedrex has 300mg of caffeine in one capsule as stated on their website.

To give some idea of how high this is, a coffee cup will contain between 50 and 475mg dependent on the brewing process, while cola drinks have 0 to 115mg per 12oz serving.

Eria Jarensis Extract

The Eria Jarensis extract comes from the Eria Jarensis orchid and is also known as N-Phenethyl Dimethylamine or N, N-Dimethylphenethylamine.

This is another stimulant gaining popularity as a replacement for banned substances such as ephedrine, DMAA, and AMP-Citrate.

Grains Of Paradise (Paradoxine)

Grains of Paradise comes from the fruit and seeds of the Aframomum melegueta plant.

There are very few studies that show what this herb does. Some preliminary work on the herb has indicated that it may stimulate the brown adipose tissue, leading to weight loss, but this study has only been done in rats.

Another study completed on rats has some inconclusive findings showing that this may have weight reduction possibilities, according to Autonomic Neuroscience, but the results must be replicated in human studies.

Synedrex ingredients

Bitter Orange Extract

Bitter Orange (Citrus Aurantium) is also known as Seville Orange, or Sour Orange, and comes from a tree native to the Mediterranean, but it is now grown worldwide. Its medicinal properties have been known for centuries, and it was originally used for constipation, cramps, and stomach pain.

In more recent years, it has gained popularity as a weight-loss supplement, and though there is some scientific support for its effectiveness in weight loss, there is debate over its safety.

This debate revolves around the alkaloid synephrine, which has a similar molecular structure to ephedra, a drug banned by the Food and Drug Administration.

According to the University of Michigan Medicine, there is insufficient data to establish clearly whether or not Bitter Orange will have the same effect as ephedra at this time.

Yohimbine HCI

Yohimbine HCI is a chemical extracted from the bark of the Yohimbine tree native to West Africa. The chemical has been traditionally used to manage erectile dysfunction in men as it enhances the blood flow to the genital area.

Its effectiveness in weight loss stems from some preliminary work done that shows that ingesting this chemical before exercise, specifically soccer in this study, may increase the possibility of stubborn fat deposits being broken down, according to Research in Sports Medicine.

Higenamine (Norcoclaurine)

Higenamine is a chemical extracted from plants such as nandina bamboo, Chinese aconite, and Lamarck’s Bedstraw. Its use is associated with being a fat burner.

Other ingredients include Hordenine, Huperzine A, Naringin, N-Methylphenethylamine, L-Dopa (stand 99%), and Poly-Thyronine.

Does Synedrex Work?

Synedrex reviews for this product are mixed, and as they are all based on anecdotal evidence, it is difficult to determine whether the product works or not. The scientific pages on the website are all blog-type pages and give no links to any scientific research. There are means of contacting a scientist directly by filling in an inquiry form on the web, but there is no indication of the scientist that will answer the question and whether they are qualified or not.

As stated, there are some positive Synedrex reviews for this product. Still, some of the individual ingredients are powerful stimulants and many customers reported unpleasant side effects after taking the product.

The Synedrex fat burner has received some positive reviews on the net, but as has been previously stated, there is no proof that the product burned the fat or if it was a simple change in lifestyle that was responsible for the change.

Some of the individual ingredients have been the subject of alternative tests. For example, Bitter Orange was the subject of a project documented in Current Therapeutic Research.

Does Synedrex work

In this project, a group of test subjects was given a combination of caffeine, bitter orange, and St. John’s Wort while a control group was given a placebo. The combination pill group was found to have lost a significant amount of weight during the six-week study.

Synedrex bodybuilding is advocated on some forums for use in the bodybuilding arena. The claim is that the product’s energizing effect will assist with the rigorous exercise routines that bodybuilders undertake.

Perhaps the best place to start would be to use one of the Synedrex coupons that are available via websites such as Couponsock and Dontpayfull.

Taking advantage of Synedrex coupons will allow you to purchase the product at a reduced price and see if the product suits your requirements or not before paying the full price. Another option along the same lines is to look for advertised free Synedrex samples.

These Synedrex samples will allow you to try a small amount of the product and again, decide if you like them or not.

Details On Synedrex And Weight Loss

The Synedrex weight loss pill is a capsule that should be taken in the morning.

No two people will react the same way to any compound, so the expected increase in your metabolic rate and the fat that you should burn may or may not happen depending on your circumstances. Many reviewers claimed to have lost no weight while using the product but others claim to have lost weight.

Those who lost weight did not give details about whether they had adjusted their diet and exercise routines while taking Synedrex weight loss pills, so there is no proof that the product was the reason for the lost weight or altered diet and exercise programs contributed to the weight loss.

The company website does have many articles on how to exercise and follow a healthy diet, so it is likely that if customers follow the suggested eating and exercise plans, they could lose weight.


How To Use (Take) Synedrex

The Metabolic Nutrition website advises that Synedrex is a strong compound and that consumers should take one capsule a day in the morning along with your breakfast. They advise that the capsule should not be taken within 6 hours of your normal bedtime as it may interfere with your sleep.

The website also advises that you drink plenty of water during the day, and one of the common complaints about this capsule was that consumers suffered from feeling thirsty all day.

Metabolic Nutrition also advises that it is good practice to stop using the product every eight to twelve weeks to allow “the body to reset itself.”

Metabolic Nutrition claims that Synedrex weight loss pills can be taken in conjunction with other Metabolic Nutrition products but advise against taking it with any other company’s product.

The website states that this product is not suitable for pregnant women, lactating mothers, prepubescent children, or anyone who suffers from a pre-existing health condition affected by a high stimulant product.

Synedrex should not be taken with any other weight loss supplements.

Synedrex side effects

Side Effects

Potential Synedrex Side Effects

Many reviews on the web indicate that there is a possibility of serious side effects when taking this product.

The reported side effects that can be attributed to some of the ingredients include:

  • Nausea
  • Sleeping issues
  • Dehydration
  • Headaches
  • Jitteriness
  • Elevated heart rate


Caffeine is a stimulant for the central nervous system and is in the same class as a methylxanthine. Too much caffeine can lead to jitteriness, a feeling of being shaky on the legs, excessive sweating, and sleeping issues. It can also lead to an increased heart rate.


Children are known to be very sensitive to yohimbine. If you are taking any medications, do not take yohimbine as it can increase the side effects.

FD&C Blue 1 and FD&C Red 40

These are two food colorants, and both have been the subject of warning notices.

Product Warnings

Synedrex Product Warnings

The Synedrex label warns:

  • Not to exceed the stated daily dose
  • Not suitable for pregnant or lactating mothers
  • Not suitable for anyone under the age of 18
  • Not to be taken in conjunction with alcohol or caffeine

Any Synedrex Lawsuits?

According to Top Class Actions, Syndrex was named in a class-action lawsuit in 2017. The lawsuit alleged that Metabolic Nutrition knowingly added an illegal ingredient, methylpentane citrate, to the formula. We didn’t find the ingredient listed on the label as of early 2019.

Synedrex alternatives

Where Can You Buy Syndrex and How Much?

You can purchase Synedrex on the Metabolic Nutrition website and other supplements and general retail locations.

  • Metabolic Nutrition: $49.99
  • Walmart (45 capsules): $33.90
  • Same Day Supplements: $49.99
  • Best Price Nutrition: $49.99

Interestingly, Syndrex is not for sale on Amazon, but other Metabolic Nutrition products are sold through the retailer.

Synedrex Alternatives

There are many alternatives to Synedrex regarding weight loss products. The most commonly cited alternatives are listed here.


Lazarus Laboratories manufacture Phentramin-D. It is advertised as a fat-burner and an appetite suppressant and is rated at a pharmaceutical level.


Phen375 has been available since 2009 and is manufactured from all-natural ingredients and is backed by a money-back 30-day guarantee.


PhenQ is another all-natural diet supplement that claims to support appetite suppression, energy production, fat burning, mood improvement, and fat suppression. The product comes with a full 60-day money-back guarantee.


Phen24 is also offered as a morning and evening routine. The product comes with a full 60-day money-back guarantee.

Lean Optimizer

This product is manufactured by HFL and is a medically formulated weight loss system. The product comes with a full 90-day 200% money-back guarantee.

What Users Are Saying

What Users Are Saying

“Gives you burst of energy but it also includes the anxious and restless feeling that takes away your appetite.”

“Best supplement I’ve ever taken! It kept me alert and focused with a great endurance increase I can’t find anywhere else. I would definitely without a doubt recommend this product to anyone with a serious diet plan and a gym membership looking to shed the pounds. This product is not meant to be a miracle drug, everything takes a certain level of commitment.”

“Worst ever. Had me throwing up for a day straight after only one pill. Way too intense for me.”

Bottom Line

The Bottom Line on Synedrex

So, will Synedrex help you lose weight? The business has been around for 20 years, and some dieters report positive results, but we feel uncomfortable giving our support because of the lack of clinical support. Plus, it bothers us that dieters reported side effects and a lack of results.

If the time has come to shed off the extra weight, our suggestion is to find a system that can meet your individual needs and is backed by multiple clinical studies.

Among the best programs we’ve found this year is one called Noom. Noom gives you everything you need to start making healthier choices, including human coaching, personalized meal plans, and food tracking with one of the largest databases in the world. What could get better than that?

Well, Noom is so confident in the formula they’re offering Dietsupplement readers a free trial offer, which we like.

Learn More About Noom »

Synedrex Customers Also Bought:
Free Trial Offer
Explanation of Chart
Garcinia Cambogia
Caralluma Fimbriata


What is Synedrex?


Synedrex is a weight loss pill that claims to suppress appetite, increase energy levels, accelerate weight loss, enhance mental clarity and concentration, and improve mood.

How does Synedrex work?


The manufacturer claims that Synedrex weight loss pills have been scientifically engineered to ensure that all the ingredients work synergistically to ensure that the user maintains their energy levels and avoids the energy slump common with the use of products that contain powerful stimulants.

Are the claims about Synedrex backed by scientific research?


While the manufacturer claims to use scientifically researched and proven ingredients, the scientific pages on the website are all blog-type pages and give no links to any scientific research.

Are there any potential side effects of taking Synedrex?


Yes, many reviews on the web indicate that there is a possibility of serious side effects when taking this product, including nausea, sleeping issues, dehydration, headaches, jitteriness, and elevated heart rate.

What is in Synedrex?


Synedrex ingredients are Caffeine Anhydrous, Eria Jarensis Extract, Grains of Paradise, Bitter Orange, Yohimbine HCL,Higenamine, Hordenine, Huperzine A, Naringin, N-Methylphenethylamine, L-Dopa, and Poly-Thyronine.

Other ingredients: Talc, Calcium Carbonate, Silicone Dioxide, Magnesium Stearate, FD&C Blue#1, FD&C Red #4, and Gelatin.

Where can I buy Synedrex?


Synedrex can be purchased using their Official Site.

What are the active ingredient in Synedrex?


The active ingredients in Synedrex are Caffeine Anhydrous, Eria Jarensis Extract, Grains of Paradise, Bitter Orange, Yohimbine HCL,Higenamine, Hordenine, Huperzine A, Naringin, N-Methylphenethylamine, L-Dopa, and Poly-Thyronine.

Does Synedrex work?


There’s no scientific research proving the effectiveness of Synedrex. There are studies linking chromium to weight-loss, but this ingredient is common and can be found online for less than $5.

How much does a bottle of Synedrex cost?


A bottle of Synedrex costs $49.99.

How do you take Synedrex?


You take one or two Synedrex capsules per day. The website recommends to check your tolerance first by taking one serving (1 capsule) in the morning with breakfast. Once tolerance has been assessed, if you are looking for an additional boost of energy, an additional serving (1 capsule), may be taken at noon or with your first serving of the day. Do not use this product within 6 hours of bedtime. Do not exceed 2 capsules per day.

Who makes Synedrex?


Metabolic Nutrition makes Synedrex.

Is Synedrex for men and women?


Both men and women can use Synedrex. The ingredients don’t address specific gender needs.

Do you need to “cycle” off of Synedrex?


You don’t need to “cycle” off of Synedrex. The website recommends stopping use for two weeks after using it for 12 weeks, however.

Do I need to exercise with Synedrex?


You don’t need to exercise with Synedrex, but the company states optimal results occur when you combine with diet and a fitness plan.

Is there a guarantee with Synedrex?


Synedrex offers a 30-day money-back guarantee.

How much weight can you lose in a week with Synedrex?


With Synedrex, it may be possible to lose up to 10 pounds in one week but this will depend on a variety of factors including diet, exercise, and individual metabolism. Synedrex is a stimulant-based fat burner that is designed to help support healthy weight loss by increasing metabolism and suppressing appetite. It can also help you maintain energy levels throughout the day so you can stay active and burn even more calories.

Can Synedrex be taken as a laxative?


No, Synedrex is not intended to be used as a laxative.

Article Sources

best scale
Scroll to Top