Lipo 6 Review – 17 Things You Need to Know

Lipo 6 Review
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Lipo-6 is original fat-burning pill produced by Nutrex and has sold so well that Nutrex now produces a number of Lipo-6 derivative products. The company assures users that Lipo-6 will deliver “accelerated fat loss.” But it’s worth mentioning that the primary ingredient in Lipo-6 is Synephrine HCL, which has had decidedly mixed results in clinical studies. While some people have lost weight under medical supervision using Synephrine, others have lost no weight while experiencing severe side effects such as jitters and nausea.

Is Lipo-6 the right fat-burner for you? Read on to learn what our research team found out about the product, and decide for yourself.

Lipo 6 can be purchased through their Official Site.

Lipo 6 Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

Lipo 6 Video Review


What is Lipo-6?

For starters, Lipo 6 is marketed as maximum strength, rapid weight loss aid that promotes energy and focus. This dietary supplement is touted as an “accelerated fat-loss formula” and comes in the form of fast-acting liquid-caps. The product aims to target stored body fat, break it down, and burn it off to promote healthy weight loss. Its fast-absorbing ingredients are pharmaceutical-strength and free of animal components. Put simply, Lipo 6 is claimed to burn off fat quickly, but does science agree?

Lipo 6 Competitors

Irwin Naturals
Fit Affinity
1-Db Goddess
Company Info

How Did Lipo 6 Start?

Lipo 6 first showed up back in 2005 and is made by Nutrex Research, Inc. It is part of their Basix Series of supplements, and it was formulated to be the world’s first liquid capsule diet pill.

This product is geared toward men, women, bodybuilders, and fitness enthusiasts alike.

There are now several options to choose from, which include:

  • Lipo-6 Defining Gel: $39.99
  • Lipo-6 Black UC: $34.99
  • Lipo-6 Black Intense UC: $39.99
  • Lipo-6 Black Hers UC: $34.99
  • Lipo-6 Hardcore: $39.99
  • Lipo-6 Black: $44.99
  • Lipo-6 Black Stim-Free: $34.99
  • Lipo-6 Black Nighttime: $24.99
  • Lipo-6 Cleanse & Detox: $27.99
  • Lipo-6 Black Probiotic: $34.99
  • Lipo-6 Black Diuretic: $24.99
  • Lipo-6 Black Keto: $24.99
  • Lipo-6 Black Thyrolean: $34.99
  • Lipo-6 CLA: $29.99
  • Lipo-6 Carnitine: $29.99

According to the official website, “It is no wonder that LIPO-6 was voted ‘Fat-Loss Support Product of the Year’ in 2005, 2006, 2007, and 2008.” They are not currently accredited by the BBB, but they have earned an “A+” rating.

Other popular products by Nutrex Research, Inc. includes ABOL, BCAA 6000, Alpha-T, T-UP, ISOFIT, Outlift, Alpha Pump, Lipo6, BCAA Intense, BCAA 6000, Vitrix, Alpha-T, and Tribulus Black.

How to Contact Lipo 6 – Nutrex Research

Nutrex Reasearch
579 South Econ Circle
Oviedo, FL 32765

  • Toll Free: 888-3Nutrex (888-368-8739)
  • Phone: 407-359-0734
  • Fax: 407-971-1459
  • Email: [email protected]

Lipo6 and the Better Business Bureau (BBB)

Though Lipo6 doesn’t have a BBB page, the parent company Nutrex Research does. They are not accredited by the BBB, there have been no customer review or complaints, yet they still manage to earn an “A+” rating by the bureau.


Lipo 6 Claims

Okay, let’s take a closer look at those marketing claims for Lipo 6 pills. Here is what this diet supplement offers:

  • First liquid capsule diet pill ever
  • Fast-absorbing liquid capsule technology
  • Accelerated fat loss effects
  • Rapid and healthy weight loss results
  • Pharmaceutical-strength ingredients
  • Natural vegetarian capsules
  • 4-time award winner for fat loss

Lipo 6 Ingredients

Now for an in-depth look at Lipo 6 ingredients to get a better understanding of what this formula has to offer. It contains the following:

Caffeine Anhydrous (200mg)

A dehydrated form of caffeine that is sometimes used in medications, pharmaceuticals, and dietary supplements. It works the same as caffeine and has stimulant effects. Caffeine comes from natural sources such as tea leaves, coffee beans, cacao pods, and kola nuts.

Synephrine HCl (20mg)

An alkaloid that is found in bitter orange (also called citrus Aurantium). It has similar effects to ephedrine and is often used in diet products as a fat burner. Like caffeine, it has stimulant effects, but some studies have shown that it may be unsafe.

Bioperine (5mg)

Also called Piperine, this is an extract from black pepper. Aside from being used as a food spice, it is often added to supplements because it has been shown to help with the body’s absorption of various nutrients, according to EODMT.

Synthetic 99% Guggulsterones Z&E 1:1 (20mg)

A human-made version of guggulsterone, which comes from the Guggul tree that claims to have some health benefits. In animal studies, guggulsterone “influenced obesity-related factors,” says the Journal of Dietary Supplements

Yohimbine HCl (3mg)

This is an indole alkaloid that comes from the Pausinystalia Yohimbe tree, indigenous to Central Africa. It has been shown in some studies to improve blood flow.

Does It Work?

Does Lipo 6 Work?

This is the question you need answering. Does Lipo 6 work as claimed? Let’s focus our attention on the key ingredients and what documented research has to say.

According to research published in Nutrition, caffeine does have beneficial effects, at least when consumed in moderation.

Studies have shown that it can help boost energy levels, reduce fatigue, improve athletic performance, enhance alertness and concentration, improve focus, and help with cognitive function.

According to the International Journal of Medical Sciences, “p-Synephrine alone as well as in combination products were shown to increase resting metabolic rate and energy expenditure, and modest increases in weight loss were observed with bitter orange extract/p-synephrine-containing products when given for six to 12 weeks.” Guggulsterones (Guggul) may help stimulate metabolism and might improve overall weight loss results.

Bioperine or piperine has demonstrated the ability to improve ingredient or nutrient absorption, which in turn helps boost product effectiveness. It is considered a bioavailability enhancer, says Current Opinion on Drug Metabolism and Toxicology.

While yohimbine has been shown to improve blood flow, which may help with erectile dysfunction, athletic performance, and weight loss.


Lipo 6 Benefits

The benefits of Lipo 6 fast-acting liquid capsules are said to include rapid fat loss and serious weight loss results.

We took a closer look at Lipo 6 reviews to gain a better understanding of what actual users had to say.

In short, there are a lot of mixed opinions on this maximum strength fat loss formula.

While some users reported better energy, and some mentioned weight loss, others complained about side effects such as dizziness, headaches, and lightheadedness.

It is worth it to take some time and read through the user feedback and customer comments for this diet product, so you get a better understanding of what others have experienced and what Lipo 6 results they have seen.

You can find Lipo 6 reviews on the official website and dealer sites such as Amazon.

Weight Loss

Details on Lipo 6 and Weight Loss

What about actual weight loss effects? Can you count on Lipo 6 to help you safely drop some pounds, or is this diet product a scam?

The Journal of the American College of Nutrition concluded synephrine taken in combination with caffeine could help increase lipolysis and fat oxidation.

A study published in the British Journal of Pharmacology concluded yohimbine might have both thermogenic and lipolytic effects.


How to Take Lipo 6

By now, you are probably wondering how I can use Lipo 6?

Well, according to the packaging, the recommended use for fat loss is to take two liquid-caps 30 minutes prior to breakfast and two more in the afternoon.

However, it is recommended to begin with only one liquid-cap each morning and afternoon, at least for the first two days, in order to adjust to this supplement.

It is important to never exceed four liquid-caps of Lipo 6 in a single day. Also, you should not take this product within 6 hours of bedtime.

Side Effects

Potential Lipo 6 Side Effects

The overall safety of Lipo 6 is a concern. We took a close look at the ingredients in this supplement, as well as the customer reviews posted online, and here are the possible Lipo 6 side effects you could experience:

  • Nausea
  • Lightheadedness
  • Stomach irritation
  • Dizziness
  • Headaches
  • Sleeping issues
  • Dehydration
  • Rapid heartbeat


Caffeine is a stimulant. It is often found in coffee, tea, and soda. It has also become a popular ingredient in many weight-loss supplements. Caffeine is commonly consumed to increase mental alertness.

According to Medicine and Science in Sports Exercise, “The additional 22% reduction in body weight, 25% reduction in epididymal fat-cell size, and 5 and 6% reductions in epididymal and retroperitoneal fat-pad weights, respectively, in the caf-ex group beyond the no caf-ex group support the hypothesis that fat loss with aerobic exercise can be increased when caffeine is ingested prior to the training sessions.”

Performance during the 45 min energy-based target time trial was significantly faster (∼5.0%) for the caffeine group and the coffee group in comparison to the decaf and placebo (38.35±1.53, 38.27±1.80, 40.23±1.98, 40.31±1.22 minutes p<0.05).

These substantially faster times were mirrored in both the caffeine as well as the coffee groups. The average power for the caffeine and coffee groups throughout the time trials were substantially better in comparison to the decaf and the placebo groups (294±21 W, 291±22 W, 277±14 W, 276±23, p<0.05).

There were no important alterations noticed between the placebo and the decaf groups during the time trials. In conclusion, both caffeine and coffee (5 mg/kg/BW, 5 mg/kg/BW, respectively) ingested 1 hour before exercise could enhance endurance exercise performance, as per PLoS One.


Also known as bitter orange, synephrine has become a popular ingredient in many supplements since ephedrine was banned by the FDA. It is considered a stimulant and is used heavily in the dieting sector. Synephrine is used to help with poor appetite, weight loss, fatigue, and more.

In a study published in Experimental Biology and Medicine, researchers tested the effects of synephrine in weight-loss supplements. They concluded, “There is little evidence that products containing C. Aurantium are an effective aid to weight loss.”

Bitter orange by itself or mixed with other products proved to elevate resting metabolic rate as well as energy expenditure, and mild elevations in weight-loss were noticed within the p-Synephrine products when administered for 6 to 12 weeks.


Guggulsterones have been consumed historically for weight loss, acne, and more. According to the Journal of Dietary Supplements, “Guggulsterones at the dose of 400 mg/kg body weight was able to significantly reduce food intake and limit body weight gain over a period of 15 days.”


Both subjective, as well as objective criteria were taken into account regarding the efficacy evaluation of Yohimbine.

The subjective principles included improved sexual desires, frequency of sexual contacts, sexual satisfaction, and erection quality during intercourse.

The objective principles of outcome were based on penile rigidity improvement, which was studied via polysomnography within the sleep laboratory. In conclusion, Yohimbine’s response rate was noted to be substantially more effective than the placebo (71 versus 45%).

It was found that yohimbine was very well tolerated, with only 7% of subjects rating their tolerability at fair or poor. Most of the negative effects reported were mild, and there were no significant adverse effects reported, as per the International Journal of Impotence Research.

Product Warnings

Lipo 6 Product Warnings

There is a long list of Lipo 6 warnings posted on the bottle label. These include the following:

  • Not suitable for people under the age of 18.
  • Do not take if you are pregnant or nursing a child.
  • Never exceed the recommended dosage.
  • Do not consume other sources of synephrine or caffeine while using Lipo 6.
  • Do not use this supplement for more than eight weeks.
  • If you are already taking medication or prescription drug, consult your doctor before using Lipo 6.
  • If you have any pre-existing medical condition, be sure to speak with your doctor before using Lipo-6.
  • Discontinue use of Lipo 6 two weeks before surgery.
  • If you experience any severe reactions such as severe headaches, rapid heartbeat, shortness of breath, or dizziness, stop taking this product immediately.
  • Lipo 6 contains ingredients that may be banned by some sports organizations.
  • Individual results from Lipo 6 will vary.
  • Keep out of reach of children.

Any Lipo 6 Lawsuits?

Nutrex was hit with a class-action lawsuit in 2010 when multiple of its products, including Lipo 6 Hers, Lipo 6 Black, and Lipo 6 Ignite, were found to contain amphetamines.

In January 2011, Lipo 6X was recalled from the Canadian market due to its potential to cause severe adverse side effects.

Although the recalls didn’t note any reports of adverse side effects, that changed when Nutrex Research, Inc. was sued for the adverse side effects two of their products, including Lipo 6 Hers Ultra Concentrated, caused per Casetext. The lawsuit also mentioned the products contain DMAA, a restricted ingredient.


Lipo 6 Price

As for the Lipo 6 cost, the MSRP listed on the official Nutrex website is $39.99 per bottle (120 liquid-caps).

This will last for 30 days. However, there is a sale price posted on the website, which is $23.95 per bottle (this may not be permanent).

There is a return policy mentioned on the Nutrex website as well. You essentially have 30 days to return Lipo 6 for a refund if you are unsatisfied, but this only applies to unopened/unused products.

If you opened the bottle of Lipo 6, you only have 15 days to return it from the time your order was received. Also, you must contact customer service before returning your order.

Where You Can Buy

Where Can You Buy Lipo 6?

There are several stores and websites that sell Lipo 6 pills, which are as follows:

  • Official Nutrex website
  • Amazon
  • GNC
  • The Vitamin Shoppe
  • Walgreens
Pros and Cons

Lipo 6 Pros and Cons

Lipo 6 Pros

  • Some Lipo 6 ingredients are supported by research.
  • Lipo 6 is readily available.
  • Some positive Lipo-6 review.

Lipo 6 Cons

  • Lipo 6 contains 200mg of caffeine per serving/400mg per day

Lipo 6 Alternatives

You can find various alternatives to Lipo 6 diet pills. There are numerous weight-loss supplements out there that help with fat burning and higher energy levels.

We suggest that you narrow your focus on products that contain safe ingredients.

As for Lipo 6, this formula uses both synephrine and caffeine (a substantial amount) to boost thermogenesis, but research has shown us that this ingredient combo can be dangerous.

While it is understandable to want weight loss results, you have to consider your safety first.

It is also beneficial to focus on user reviews to learn more about the product, and always find out if the diet supplement comes with a money-back satisfaction guarantee.

Nutrex Lipo 6 Black

Lipo 6 Black is an even more intense weight loss support formula available from Nutrex Research.

It aims to enhance metabolic rate, provide high energy and better focus, and better control your appetite to help balance food intake.

Here is a look at the ingredient label for Lipo 6 Black:

  • Choline: 100 mg
  • L-Tyrosine: 250 mg
  • Caffeine Anhydrous: 220 mg
  • Theobromine: 125 mg
  • Grains of Paradise: 25 mg
  • Black Pepper Fruit Extract: 5 mg
  • Yohimbe HCl: 3 mg
  • Rauwolscine: 1 mg
  • Huperzine-A 1%: 100 mcg

As you can see, Lipo 6 Black contains even more caffeine and synephrine than the original formula. This is why it is labeled as “extreme potency” and has an even more extensive warning label on the bottle.

You are taking six capsules a day, instead of the four capsules you would take with plain Lipo 6.

As for the cost of Lipo 6 Black, it is listed as $44.99 per bottle (120 servings/20-day supply).

There are also plenty of Lipo 6 Black reviews posted on the main website so you can see what users have said about this product.

Nutrex Lipo 6 Black Ultra

Yes, there is also a Lipo 6 Black Ultra Concentrate, and you only need to take one capsule each morning and afternoon (30 minutes before meals).

It simply contains an Ultra Concentrated Fat Loss Support Complex of 294.5mg per serving/dose. These ingredients are as follows:

  • Rauwolscine
  • Caffeine Anhydrous
  • Yohimbine HCl
  • Theobromine Anhydrous
  • Advantra Z Citrus Aurantium (50% p-Synephrine)

Lipo 6 Black Ultra Concentrate provides extreme fat loss support, ramps up energy levels, and promotes serious weight loss.

It boasts super strong effects and the highest potency.

Lipo 6 Black Ultra Concentrate sells for $34.99 (60 servings/30-day supply), with a sale price of $20.99. Note that it cannot be used longer than 60 consecutive days.

This supplement aims to help with rapid weight loss results, as well as heightened energy and focus.

This product is advertised as a clinically-dosed maximum strength, rapid weight loss aid for both women and men. It is available for $34.99 per bottle (30-day supply).

What Users Are Saying

What Users Are Saying

“Noticeable increase in energy but for a very short time. Doesn’t even really last for an entire work out and then a serious crash quickly. I’ve taken pre-workout supplements on and off from time to time. I’ve taken Lipo 6 back when it had Synephrine in it, and although it made me irritable and on edge, I could say that it helped me to have an amazing work out for at least an hour to an hour and a half and then even when I left the gym I still had energy. This supplement might give me a burst of energy for maybe a half an hour tops but immediately after I feel exhausted as if I’d gotten three hours asleep. Consistently every time I’ve taken this supplement I’ve been exhausted afterwards.”

“This works best for me as a “fat trapper” and appetite control. Stable energy with no jitters! Helps me maintain the weight I want.”

“Love this product! Works great and gives me energy for a great workout! Also helps suppress my appetite! Been taking Nutrex Lipo 6 Black products for a long time and the Intense is awesome!”

Bottom Line

The Bottom Line on Lipo-6

Is Lipo-6 the right one for weight-loss? Well, we like that we found some favorable customer comments and that it uses a few natural ingredients, but we’re a bit hesitant about this one because there’s no research supporting claims that you’ll lose weight. Also, we’re concerned about customer reviews talking about negative side effects and no results.

If you’d like to slim down, we suggest going with a program backed by research, that’s shown to work.

Among the best products we’ve seen this year is one called Noom. The multi-faceted approach to weight loss includes personalized meal plans, human coaching, an extensive food database and more. You get what science, and users, says works.

Also, the makers of Noom are so confident in their product that they’re offering a free trial offer.

Learn More About Noom »

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Lipo 6

What is Lipo 6?


Lipo 6 is a dietary supplement marketed as a maximum strength fat burner. It comes in the form of fast-acting liquid capsules and is designed to help promote rapid weight loss by breaking down and burning stored body fat. The product contains ingredients like caffeine, synephrine, piperine, and guggulsterones, which are said to boost metabolism and fat loss. Lipo 6 is made by Nutrex Research, Inc.

How does Lipo 6 work?


Lipo 6 is said to work by targeting stored body fat and helping to break it down and burn it off. The primary ingredients—caffeine, synephrine, and piperine—are stimulants that can boost metabolism and fat burning. The guggulsterones are claimed to influence obesity-related factors to aid weight loss. By combining these ingredients, Lipo 6 is purported to enhance fat loss and lead to more rapid weight reduction. However, the effects can vary and the ingredients may cause side effects in some users.

What are the potential side effects of Lipo 6?


Possible side effects of Lipo 6 include:

  • Nausea
  • Lightheadedness
  • Stomach irritation
  • Dizziness
  • Headaches
  • Sleep issues
  • Rapid heartbeat

The stimulants in Lipo 6 like caffeine and synephrine can lead to these side effects, especially in high doses or for people sensitive to stimulants. Some users also report dehydration and other issues. It’s best to follow the dosage instructions carefully and talk to your doctor before using Lipo 6 to determine if it’s safe and appropriate for you based on your health and any medications you take.

What are the ingredients in Lipo 6?


The ingredients in Lipo 6 include:

Caffeine anhydrous (200 mg): A dehydrated form of caffeine, which is a stimulant that can boost metabolism and fat burning.
Synephrine HCl (20 mg): An alkaloid from bitter orange that acts as a stimulant and may help with fat loss. However, it can potentially lead to side effects and safety concerns.
Bioperine (5 mg): An extract from black pepper that helps with nutrient absorption. It’s used to boost the effects of other ingredients.
Guggulsterones Z&E 1:1 (20 mg): A compound from the guggul tree that’s claimed to aid weight loss, though research is limited.
Yohimbine HCl (3 mg): An indole alkaloid from yohimbe bark that can improve blood flow and may enhance fat loss. However, it can lead to side effects in some users.

What is the active ingredient in Lipo-6?


The active ingredient in Lipo-6 is a proprietary blend of bioperine, caffeine anhydrous, yohimbine HCL, guggulsterones and synephrine HCL.

Where can I buy Lipo 6?


Lipo 6 can be purchased using their Official Site.

Does Lipo 6 work?


Lipo 6 contains some ingredients like caffeine and synephrine that may help boost metabolism and fat loss to some extent. However, the effects can vary in individuals and the ingredients may cause side effects. There is also limited evidence for the effectiveness of the guggulsterones and the overall Lipo 6 formula for weight loss. While some users report losing weight with Lipo 6, many others do not see noticeable results or experience negative effects. Due to the potential issues with the ingredients and mixed customer reviews, the effectiveness of Lipo 6 is unclear. It’s best to talk to your doctor before using this or any supplement for weight loss.

How much does one bottle of Lipo-6 cost?


One bottle of Lipo-6 costs $39.95.

How do you take Lipo-6?


You will need to take two Lipo-6 capsules in the morning and one in the evening. The company suggests not taking more than six per day and not within six hours of sleep.

Who makes Lipo-6?


Nutrex Research is the makers of Lipo-6.

How much caffeine is in Lipo-6?


Each serving (two capsules) of Lipo-6 contains 200mg of caffeine.

Is Lipo-6 just for men?


No, Lipo-6 can be used by men and women. The product doesn’t contain gender-specific ingredients.

Do you need to exercise when taking Lipo-6?


The company recommends including fitness to maximize results, but no specific program is provided.

Is there a guarantee on Lipo-6?


There’s no guarantee for Lipo-6 mentioned.

What is the best time to take Lipo 6?


In general, it is recommended to take Lipo 6 shortly before or with a meal. Taking the supplement in the morning is usually best, as this will help rev up your metabolism and give you an energy boost throughout the day. It is important to always follow the instructions on the label when taking any type of supplement, and never exceed the recommended dosage.

What is synephrine HCL?


Synephrine HCL is an alkaloid found in bitter orange and is often used in diet products as a fat burner. Like caffeine, it has stimulant effects, but some studies have shown that it may be unsafe.

Is Lipo-6 suitable for vegans?


Yes, Lipo-6 is suitable for vegans, as it is free of animal components and contains natural vegetarian capsules.

Does Lipo-6 have any animal-derived ingredients?


No, Lipo-6 is free of animal components and is suitable for vegans.

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