Isotonix Review – 14 Things You Need to Know

Isotonix Review
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Isotonix offers you the maximum benefit from vitamins and nutrients. The company’s supplements range from weight loss aids to wellness products and multivitamins. We soon discovered they all come with a considerable price tag, however, making it a poor option for those trying to stay on budget.

Most of their products range from $60-100+, and our researchers found many cheaper alternatives on the market. In the bottom line, though, we gave them the benefit of the doubt and compared Isotonix’s “quality” ingredients to their product claims to see if this company is worth investing in.

Isotonix can be purchased through their Official Site.

Isotonix Readers: Noom is offering our readers a risk-free trial, for a limited time. Click here for more information!

What is Isotonix?

Isotonix claims to be the world’s most advanced nutraceutical that provides supplements made of the highest quality natural ingredients. The products include scientifically advanced formulas designed to ensure that your body receives the essential vitamins, minerals, and nutrients required for long-term health and optimal nutrition. It manufactures four essential supplements: Isotonix OPC-3®, Isotonix Multivitamin, Isotonix Activated B-Complex, and Isotonix Calcium Plus.

These supplements are multivitamins and minerals, but do we really need to supplement or is food a better option?

  • Advanced Pharmaceutical Bulletin – “The consumption of a daily multivitamin among people all over the world is dramatically increasing in recent years. Most of the people believe that if vitamins are not effective, at least they are safe. However, the long term health consequences of vitamins consumption are unknown.”
  • Europe PMC – “… self-medication with vitamins, minerals or FSs shows a high user prevalence which has increased significantly over time. In light of potential interactions with prescribed medicines the results show the importance of ascertaining self-medication with vitamins, minerals and FSs in medical practice.”
  • Archives of Public Health – “The adequacy of micronutrient intake is a public health concern, as both insufficient and excessive intake levels may result in adverse health effects.”

Isotonix Competitors

Plexus Slim
Usana Essentials Multivitamin

Other similar products: , NeoCell, ,

Company Bio

How Did Isotonix Start?

Market America, a product brokerage and internet marketing company, was founded in 1992 by JR and Loren Ridinger. Its headquarters is in Greensboro, N.C. and the Company employs over 650 people as of 2010.

The firm manufactures various products such as dietary supplements, cosmetics, auto care, jewelry, household cleaning supplies, personal care products, custom websites, water purifiers, and weight management products.

In 1993, it started manufacturing Isotonix products and had been manufacturing them since then.

Market America operates as a multi-level-marketing (MLM) business.

Market American earned an “A+” rating with the BBB along with 4.45 out of 5 stars based on an average of 29 customer reviews. They’ve closed 14 complaints customers lodged with the BBB in the past three years.


Isotonix Claims

Isotonix supplements claim to provide your body with the maximum benefit it can receive from vitamins and minerals. It offers a complete array of multivitamins, weight loss supplements, and wellness products, which will fit your needs and provide unique health benefits.

How Does It Work?

How Does Isotonix Work?

The term Isotonic refers to having the “same pressure.” That means that its chemical makeup is similar to your body’s plasma, blood, and tears.

Hence, all fluids in your body have a particular concentration, referred to as ‘osmotic pressure.’

The body’s standard osmotic pressure is isotonic.

According to this logic, a substance entering the body must be in the isotonic state to be absorbed, transported, and readily available for its metabolism.

Isotonix dietary supplements come in an isotonic solution. Unlike pills that take time to disintegrate, and for their contents to be fully dissolved and transformed into the proper isotonic state.

During this time, much of their activity is lost. During digestion, the essential micronutrients in pills and capsules can get trapped by fats, fibers, tannins, or inactivated by the stomach’s highly acidic pH level.

However, Isotonix supplements are already in disintegrated powdered form. This means that less work is required to obtain maximum absorption, and therefore, the nutrients are transported directly into the small intestine and quickly absorbed into the bloodstream.

When the Isotonix products are consumed in this fashion, the supplements do not lose their nutritional value and make the absorption of nutrients highly efficient while delivering maximum results.


Isotonix Ingredients

isotonix ingredients

Isotonix consists of all-natural ingredients that include:

Grape Seed

According to Antioxidants, grape seed extract is typically taken from the seeds of red grapes (instead of white), which contain high levels of oligomeric proanthocyanidins (OPCs) complexes. Grape seed extract is extremely rich in antioxidants.

It contains the polyphenol-a compound, with high antioxidant activity.

Red Wine Extract

Red wine extract is a powerful antioxidant that is present in seeds, stalks, vines, and roots of grapes, with the highest concentration in the skins. This is because it contains resveratrol, per Biomedicines

The antioxidant properties of red wine extract can help to maintain healthy circulation by strengthening capillaries, arteries, and veins, according to Molecules. reports that Resveratrol present in red wine extract help enhance memory and enhance joint mobility.

Pine Bark

Pine bark extract is an all-natural combination of procyanidins, bioflavonoids and organic acids, per Frontiers in Psychology. Most importantly it consists of a potent antioxidant compound called pycnogenol.

The extract’s antioxidant properties selectively bind to collagen and elastin and promote the production of endothelial nitric oxide, which is responsible for the dilation of blood vessels.

It also helps support healthy blood platelet activity, alleviates menstrual cramping and abdominal pain, maintains joint flexibility, ensures healthy sperm production supports a healthy complexion.


Bilberry extract is derived from the bilberry plant that has bright green leaves and bell-shaped flowers and is grown in northern Europe, per Herbal Medicine. It is closely related to blueberry, huckleberry, and cranberry.

It is rich in pigments known as anthocyanins, which are powerful antioxidants.

Scientific studies confirm that bilberry extract supports healthy vision and venous circulation, per Molecules


Citrus contains disease-fighting antioxidants called bioflavonoids. According to Food Chemistry, they are scientifically proven to help maintain healthy circulation, reduce obesity and demonstrate anti-inflammatory activity.

Weight Loss

Isotonix and Weight Loss

isotonix weight loss

Isotonix supplements consist of all-natural ingredients that help you to achieve long-term health and fitness goals. They do not contain any ingredients that cause weight gain or stimulate hunger cravings.

The multivitamin supplement provides you with the right amount of nutrients that your body requires. It helps boost your metabolism, providing you with a healthy skeletal system and muscle contractions while increasing your energy level.

Hence, you can enjoy your workout sessions for a longer period and trim down your fat quickly, without easily feeling tired or fatigued.

All of the Isotonix products have the following properties in common:

  • Gluten-Free
  • No detectable GMOs
  • No artificial preservatives
  • No Fillers
  • Vegetarian
  • Isotonic-Drinkable supplements

Isotonix supplement products include:

Isotonix OPC-3®-Single Bottle (30 Servings)

Isotonix OPC-3 is a dietary supplement that contains some of the most potent bioflavonoids currently known to research scientists.

The purest and best-researched OPCs have extracted bilberries, grape seed, and red wine.

Pycnogenol, a powerful antioxidant, is extracted from citrus fruit and pine bark.

Isotonix OPC-3 has been shown to provide a variety of health benefits including, but not limited to:

  • Combating free radicals
  • Showing anti-inflammatory activity
  • Maintaining healthy circulation
  • Strengthening capillaries, arteries, and veins
  • Alleviating menstrual cramping
  • Supporting visual health/visual activity
  • Promoting healthy blood vessel dilation
  • Boosting healthy nitric oxide levels
  • Supports a healthy skin complexion
  • Promoting healthy platelet activity
  • Promoting healthy sperm quality

Isotonix Multivitamin with Iron-Single Bottle (30 Servings)

All-Natural Isotonic Multivitamin contains 100%, or more, of the recommended daily value of essential vitamins and minerals. Hence providing you with the maximum nutrients that your body will require while replacing dietary deficiencies. It offers a wide array of health benefits that include:

  • Enhancing normal cognitive activity
  • Promoting skeletal, muscular & skin health
  • Promoting the conversion of food into energy
  • Fostering healthy growth and repair of tissue
  • Actively metabolizing fats and carbohydrates to support fat loss
  • Supporting a robust cardiovascular system
  • Supporting strong bones

Isotonix Activated B-Complex-Single Bottle (30 Servings)

This supplement contains high vitamin B6, B12, and folic acid levels, which boost your body’s vitamin B levels. As a result, offering you a wide array of health benefits that include:

  • Increasing energy and fuelling optimal energy production
  • Promoting a healthy nervous system, bone marrow, and intestinal tract
  • Regulating healthy levels of serotonin, hence decreasing stress and improving mood

Isotonix Calcium Plus-Single Bottle (90 Servings)

This supplement contains high levels of calcium that is essential for:

  • Maintaining strong bones, healthy teeth, and gums
  • Supporting skeletal health
  • Promoting normal regulation of enzyme and hormone production

Some other popular Isotonix products include:

  • Isotonix Digestive Enzymes with Probiotics
  • MochaTonix
  • Isotonix Daily Essentials Kit
  • Isotonix Complete Greens
  • Isotonix Essentials Turn Up
  • Isotonix Peak Performance Blend

Superior Quality of Isotonix Products

All the raw materials used to manufacture Isotonix are verified and require a Certificate of Analysis (COA) to be approved. Raw materials that pass this step are subjected to laboratory confirmation of physical characteristics and material potency, followed by microbiological contamination and heavy metals detection.

Each Isotonix product is then carefully prepared, and all of its manufacturing records are in written format. Every batch is carefully reviewed and approved by Market America’s highly trained quality control personnel. Audits are conducted at the warehouse to detect any damage and confirm label accuracy, appearance, taste, and identity before selling it.

Each production facility is required to meet GMP (Good Manufacturing Practice) standards by regular monitoring and is approved by either the Food and Drug Administration or the United States Department of Agriculture for their strict adherence to Standard Operating Procedures, employee training, product specifications, and supplier/vendor qualification procedures.

Benefits and Results

Isotonix Benefits and Results

isotonix benefits

Isotonix supplements consist of a combination of several ingredients that offer unique health benefits regarding energy, immunity, muscle mass growth, and digestion.

It is popular amongst athletes and people who want to get rid of their never-ending fat belly. Many users take it before work out sessions as it boosts their energy levels and provides them with maximum strength and stamina.

A high quantity of vitamins provides you with increased immunity against diseases and boosts your overall metabolism.

It is also a beneficial supplement for older people. It helps them manage daily tasks without any complaints about muscle contractions and feeling fatigued, hence providing a healthy lifestyle for people of all ages.


How to Use (Take) Isotonix

All Isotonix supplements come in powdered form and mixed with water before drinking.

To ensure that the isotonic solution flows immediately into your small intestine, make sure you take it on an empty stomach.

This process utilizes the supplement more efficiently due to the increased absorbability, hence giving optimum desired results.

Why is Gastric Emptying Time Stressed When Talking about Isotonix?

Nutrients that are already isotonic will not be broken into an isotonic state. Therefore, gastric emptying occurs more rapidly. Biological sensors in the gastrointestinal tract detect that the ingested solution is isotonic and at a correct pH. This causes the pyloric valve at the lower end of the stomach to remain open, allowing the concentrated solution to be squirted into the small intestine by stomach contractions. Absorption of the nutrients by the intestinal mucosa then starts to occur.

Isotonix products are to clear your stomach at an optimal rate to maximize absorption. A pill does not fully deliver into your bloodstream the vitamins it holds within. Either the medication is dumped whole into your intestinal tract or the active ingredients pass through without being fully absorbed.

Vitamins taken in isotonic form do not have these shortcomings. Thus, it is necessary to consume Isotonix supplements on an empty stomach.

Product Warnings

Isotonix Product Warnings

Isotonix products are free of harmful chemicals, preservatives, and alcohol.

For optimum results, stick to taking Isotonix with water. Avoid mixing it with soda, milk, juice, coffee, tea, etc. It should be stored in a dry and cool place, ideally in a dry cabinet.

Avoid keeping it in your bathroom and keep out of children’s reach. If you are storing it in the kitchen, make sure it is far away from the sink, stove, window ledges, and heat-generating appliances.

If the weather conditions are very humid, you may keep it in the refrigerator but far from the fruit and vegetable area because it has high humidity. Note that moisture from the air quickly condenses on cold items taken out from a refrigerator.

The supplement’s sugars quickly absorb moisture and cause hardening of the power, commonly referred to as ‘caking.’

Return Isotonix products immediately back into the refrigerator after using it.

Ensure you clean and dry the screw cap’s threads before putting the bottle back into the refrigerator. Any amount of moisture will accumulate on the bottle resulting in caking. Ensure the cap screw is tightly closed at all times and avoid leaving it open for more than a few minutes.

If you note that the powder is hardening, shake the bottle contents a few times during the cool-down period. This will help prevent it from hardening into a solid mass.


Any Isotonix Lawsuits?

isotonix lawsuits

In 1999, Market America and its CEO faced certain charges imposed by the United States Security and Exchange Commission concerning how the Company started in 1994. The Company was thought to be selling unregistered Market America stock.
However, the case settled after Market America paid a hefty fine of $100,000 and $235,498 to the SEC. The firm did not admit or deny any of the allegations. In 2001, the firm’s CEO settled to avoid any future violations of the federal securities laws, and the Company went private.

On March 3, 2006, Steve Sawyer sued Market America to pay him for $8,333.34 in monthly services and a $25,000 bonus.

In 2007, the court ruled in favor of Sawyer’s claim that Market America went against the North Carolina Wage and Hour Act by violating its workers’ rights. Sawyer appealed to the North Carolina Court of Appeals, which ruled the trial court’s decision in favor of Market America in June 2008.

Sawyer appealed to the North Carolina Supreme Court and was denied review on December 11, 2008.

Based on the same facts as the North Carolina lawsuit, Sawyer filed a lawsuit against the firm in Multnomah County, Oregon, on December 26, 2008.

Moving into 2009, Market America decided to take the North Carolina lawsuit to trial. Sawyer filed a motion to stay the North Carolina lawsuit, which the judge granted.

Later that year, Market America filed a motion to stay the Oregon lawsuit, which the judge granted. In 2010, Sawyer saw a denial for the review to keep the Oregon Supreme Court’s Oregon lawsuit.

In a 2017 federal lawsuit, a party accused Market America of violating the Racketeering Influenced and Corrupt Organizations Act and California state law.

The suit claims that the Company is very biased and targets only Chinese-American immigrants for their own money-making business.

By doing this, it aims to sell products to their friends and relatives in Asia. The lawsuit characterized Market America’s business practice as “racketeering.” It accused that “while the executives tell distributors they can earn more than $560,000, only those at the top make that kind of money. Ninety percent of sellers do not receive a penny”.

On May 13, 2019, Chuanjie Yang sued Market America in a class-action lawsuit for acting like a pyramid scheme, according to Class Action.

February 2020 also saw a new accusation from the FDA. A warning letter, sent to COO Marc Ashley, spoke of a failure to report adverse effects. It also brought up issues with label compliance for several of their products. We will be keeping an eye on any upcoming updates regarding the warning letter.


Isotonix Alternatives

Many other companies produce a similar product to Isotonix, as listed below. They all contain natural, high-quality ingredients, ideal for achieving your targeted weight loss and fitness goals.

They do this by suppressing appetite and providing an explosive amount of energy to users to perform intense physical activity and workouts without feeling hungry or tired.

Following is a quick list of some of the best-related diet pills:

  • Phenocal
  • PhenQ
  • Lipozene
  • Slim Optimum
  • Adiphene
  • Lipozene
Customer Service

Customer Service Contact Info

What Users Are Saying

What Users Are Saying

“I have been off and on OPC-3 for the better part of a decade. I have noticed improved circulatory function and just a good feeling.”

“Even if I took a double dose of this, it would not supply the recommended daily dose of calcium for a woman. Very disappointed that I didn’t check the label before purchasing this item. The taste is palatable.”

“Tangy tasty multivitamin to energize you while providing nutritional benefits.”

Bottom Line

The Bottom Line on Isotonix

So, the last of the facts have trickled in. What’s our take on this one? We like the fact that Isotonix has been on the market for over ten years and that it seems to have developed a cult-like following. We also like the results that some users have seen and that the product is readily available, but we have reservations recommending this because of the more affordable alternatives on the market that accomplish the exact results. We’re also concerned about the inconvenience of mixing the powders.

If you’d like a convenient, affordable way to lose, we suggest a program that provides healthy and steady weight-loss and is backed by multiple clinical studies.

Among the best programs we’ve seen this year is one called Noom. This weight loss system provides its users with everything they need to start losing weight the right way, like human coaching, personalized meal plans, and support groups.

The makers of Noom are currently offering Dietsupplement readers a  free trial offer, which is a sign that they’re confident in their program.

Learn More About Noom »

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What is Isotonix?


Isotonix is a line of supplements that claims to offer maximum benefits from vitamins and nutrients. The company offers a range of supplements, from weight loss aids to wellness products and multivitamins.

How does Isotonix work?


Isotonix dietary supplements come in an isotonic solution, meaning that their chemical makeup is similar to the body’s plasma, blood, and tears. This allows for maximum absorption, as the nutrients are transported directly into the small intestine and quickly absorbed into the bloodstream.

How did Isotonix start?


Isotonix was started by Market America, a product brokerage and internet marketing company founded in 1992 by JR and Loren Ridinger. Market America operates as a multi-level-marketing (MLM) business.

What are some Isotonix competitors?


Some competitors to Isotonix include Plexus Slim, Isagenix, Usana Essentials Multivitamin, and Nutrilite.

What are some of the properties that all Isotonix products have in common?


All Isotonix products are isotonic drinkable supplements that are vegetarian and free of artificial preservatives and fillers.

Where can I buy Isotonix?


Isotonix can be purchased using their Official Site.

What is Isotonix multivitamin?


The Isotonix multivitamin is a preparation of vitamins and dietary minerals. It is available with or without iron added.

What is Isotonix digestive enzymes good for?


The Isotonix Digestive Enzyme formula helps control cholesterol levels, supports a healthy gastrointestinal tract and immune system, aids in digestion and in the absorption of nutrients.

What are the side effects of Isotonix?


Isotonix products side effects may include headaches.

What are the ingredients in Isotonix?


Some of the ingredients found in Isotonix products are chromium, l-carnitine, pycnogenol, resveratrol, acai, coenzyme Q10, vitamins, minerals and lutein. The formulas differ depending on the supplement.

Does Isotonix work?


There are no scientific studies linking Isotonix to weight-loss. We did find research into some active ingredients, like chromium, but that ingredient is used in other products.

How much does Isotonix cost?


Isotonix costs vary by supplement. The Isotonix® Magnesium costs $41.95. You can also find  MochaTonix® (Fat Burning. Nutrient Enhancing. Energy Boosting), for $39.95.

How should I take Isotonix?


You should take Isotonix based on the supplement purchased.

Are Isotonix supplements gluten-free?


Yes, Isotonix supplements are gluten-free, and they also do not contain detectable GMOs, artificial preservatives, or fillers.

Do Isotonix products contain soy?


Yes, several of the Isotonix products contain soy.

Does Isotonix come with a guarantee?


Isotonix comes with a guarantee. You’ll receive a return authorization and send the unopened item back for a full refund.

Is Isotonix FDA approved?


Isotonix products are not approved by the FDA.

Are Isotonix vitamins any good?


Vitamins in general may be able to help balance out nutritional deficiencies you may have with your diet.

Is Isotonix organic?


Isotonix is not organic, but it is all-natural. Isotonix’s ingredients are sourced from natural sources and contain no synthetic preservatives or additives. This dietary supplement contains antioxidants, vitamins, minerals, and plant extracts that help support overall health. Isotonix is also free of common allergens such as wheat, milk, eggs, fish, peanuts, and tree nuts.

What is Isotonix OPC-3?


Isotonix OPC-3 is a dietary supplement that contains some of the most potent bioflavonoids currently known to research scientists. The purest and best-researched OPCs are extracted from bilberries, grape seed, and red wine.

Can Isotonix supplements help with weight loss?


Isotonix supplements consist of all-natural ingredients that help you achieve long-term health and fitness goals. They do not contain any ingredients that cause weight gain or stimulate hunger cravings. The multivitamin supplement can help boost metabolism, provide a healthy skeletal system and muscle contractions, and increase energy levels.

Does Isotonix have a good reputation?


Market American, the company that manufactures Isotonix, earned an “A+” rating with the BBB and 4.45 out of 5 stars based on an average of 29 customer reviews. They’ve closed 14 complaints customers lodged with the BBB in the past three years.

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